The focus of this PhD project is the effects of a potential disease modifying osteoarthritis drug (DMOADs) on articular cartilage turnover in models of OA. Both in vitro, ex vivo and in vivo models will be used to investigate the direct and pharmacodynamic effects on cartilage turnover, joint protection and pain. The models will be assessed by biomarker and histological analysis. With this we hope to characterize the tissue changes leading to cartilage formation in response to this drug.

The project investigates neuronal communication (NC) during resting states and cognitive processing with focus on pre-attentive and attentive processing, shown to be altered in Alzheimer's disease and schizophrenia, using advanced data analysis of electrophysiology. The potential of capturing relations in biological signalling relevant to cognition is investigated, i.a. from single-neuron-recordings, and the possibilities for inter-species translation of (NC) and cognition markers are explored.

IT Projects face problems despite IT processes and Project Management Methodologies being well in place. This project uses sociology theory as lens to analyze IT projects to first describe their problems in socio-technical context and then uses same lens to look for solutions to the IT project problems. Sociology theory is used to investigate internal working of IT teams by treating them as social systems and investigating how knowledge, processes and methodologies are interpreted and applied.

Overordnet målsætning er at tilvejebringe dokumentation for effekterne af forædlet valleprotein hydrolysater (VPH) fra humane interventionsforsøg. Projektet vil klarlægge strategier for indtag af forædlede VPH til optimering af træningsadaptioner i atleter og overvægtige, som ønsker forbedringer i hhv. præstation og helbredsparametre. De teoretiske forventelige resultater vil give baggrund for et mersalg af VPH til udvikling af nye produkter til gavn for industrien men ligeledes forbrugeren.

Cue is an IoT system of easily deployable sensors connected to a smartphone application and a wristband, that enables hearing and visually impaired people to create a home better suited their needs.

Despite the obvious advantages of continuous blenders, like high productivity and reduced scale-up activities, are those still due to lack of knowledge of the capabilities and constraints not fully implemented in pharma industries. Objectives of the project are to benchmark a continuous blender against traditional batch blenders, apply novel powder characterization methods to understand flow behavior and gain new knowledge on utilization of NIR spectroscopy as process analytical monitoring tool

Goal of this project is to enhance the scientific understanding of the mechanisms involved in plaque stability/instability in pre-clinical mouse models and human patients, as well as to explore and identify mechanisms explaining the enhanced vulnerability of plaques in T2D patients. Identification of biomarkers that translate from pre-clinical mouse models to humans and an enhanced knowledge of mechanisms involved in the progression from stable to high-risk unstable plaques, are needed.