The aim of the project is to demonstrate the value of targeted bacteriophage treatments in reducing the impact of antibiotic resistant E. coli strains, using chicken septicaemia as a model. This project also has the potential for significant One Health impacts, given the similarities between pathogenic E. coli strains that infect animals and humans. It is also a proof-of-concept project for other bacterial pathogens of livestock.

ErhvervsPhD

Novo Nordisks patienter er dybt afhængige af at have adgang til innovative devices med høj pålidelighed. Øget brug af varians-baserede simuleringer i udviklingsprocessen ville kunne give design ingeniørerne en øget forståelse af hvordan devicet vil fungere i hele udfaldsområdet, dvs. inkl. varians fra produktion og brug. Udvikling af en proces og metoder til at lave sådanne simuleringer vil muliggøre hurtig udvikling af innovative og pålidelige devices, hvilket kommer patienterne til gode.

Parkinson’s sygdom er karakteriseret ved tab af dopamin neuroner i substantia nigra der medfører en ubalance imellem to sæt af projektions neuroner der danner den ’direkte vej’ og den ’indirekte vej’. I dette projekt vil vi forstå de neurokemiske ændringer der forekommer i hjerneregioner neden strøms for disse to sæt projektions neuroner efter aktivering eller deaktivering. Projektet vil øge den systemiske forståelse af patologien bag Parkinson’s sygdom til gavn for udvikling af lægemidler.

The scientific objectives of the MetaCat consortium are to deliver enzyme collections to industries, which encompass a high percentage of AFH enzymes (“all-round” and “frequent h it” enzymes). The enzyme classes we strive for include nitrilases, transaminases, ketoreductases, glycosyl hydrolases and lipases/esterases, which are of utmost importance for biotechnology. They can be implemented in the production of fine and platform chemicals, chiral building blocks and many other high-value compounds and their application usually results in a speed-up of synthesis routes and thus a significant reduction of the time to market. Special attention is paid to robust enzymes accepting large and bulky substrates

Fase 1 er udvikling af CAPILLAQUA bæredygtig pottebakke med vandingssystem til transport af potteplanter. Systemet er "new to the world". Det medfører minimalspild, øget kvalitet af blomster og krydderurter fra jord til vindueskarm og løfter bæredygtigheden i branchen. 7 repræsentanter fra alle brancher i kæden fra gartneri til detail deltager i udviklingen og bliver fremtidige kunder. Der transporteres over 500.000.000 planter (min.10% spild) om året alene i DK i bakker med ca. 10 stk.

Peptider er en lovende klasse af molekyler til behandling af en lang række sygdomme. I nærværende projekt ønsker vi at udvikle en ny peptid-screenings platform som muliggør direkte selektion af enkelte funktionelt aktive peptider fra peptid-biblioteker som indeholder op til milliarder af individuelle peptider. Det forventes at etablering af en sådan screenings platform vil øge mulighederne for hurtigere at finde terapeutiske peptider med nye virkningsmekanismer og ønskede egenskaber.

What is the innovation and the need behind the innovation?: ‘SWISS’ will provide an innovative system towards real-time monitoring of water quality by detecting series of contaminants through Biochemical Sensory Array Device (BSAD).; What is the most important competing solution?: SWISS will develop multiple modules in a single platform including Sample Module (SM) and Analysis module (AM). ; Who will ultimately receive the value created?: Water surveillance authorities in both Denmark and India; Customers and water stakeholders.; What will the applied investment from Innovation Fund Denmark mainly be used for?: Build biochemical sensor to selectively detect heavy metals, Develop real-time data processing and alarming system.; How will the project results be implemented? The developed systems will be used to monitor water quality in selected sites in Denmark and India.

Windar Photonics A/S er en dansk virksomhed som producerer og sælger laser radar (LIDAR) vindmåleudstyr til vindmølleindustrien. Vindmåleren, som placeres i toppen af vindmøllen, kan øge den samlede energiproduktionen fra vinden med 1-4%. I denne projekt vil gerne designe og udvikle en special linse der kan forbedre sensitivitet og reducere prisen på vores nuværende product.

What is the innovation and the need behind the innovation?: An integrated power converter and battery energy storage system to meet multi-functional requirements for active and reactive power control and harmonic filtering in large wind power plants.; What is the most important competing solution?: There are 3 different devices: - STATCOM, - BESS and - Harmonic power filter (active/passive).; Who will ultimately receive the value created?: The wind power industry and equipment manufacturers will directly benefit from the proposed integrated device. ; What will the applied investment from Innovation Fund Denmark mainly be used for?: For salary of the research personnel at AAU, ØWP and ABB and for the proof of concept through real-time simulations.; How will the project results be implemented? After the techno-economic feasibility, the product will be implemented in a real WPP for field demonstration to reach TRL-6.

ErhvervsPhD

Adenium is developing AA139 as a novel class inhaled antibiotic for treating respiratory infections in cystic fibrosis patients. There is a clear need for new treatment options since the outcome of available treatments is limited by increasing resistance development, narrow efficacy spectra and suboptimal treatment regimens. AA139 shows great promise to meet the requirements and presents a compelling commercial opportunity. This project focuses on the safety of inhaled AA139.

ErhvervsPhD