Ammonia (NH3) is envisioned as a key future sustainable fuel for the marine sector. NH3 is attractive for obtaining zero carbon emissions, and it can be stored as a liquid with an acceptable energy density. NH3 is also a clean energy carrier, which can be produced with renewable power in PtX processes. In this project the consortium will develop and demonstrate a solution that improves combustion properties of NH3 by hydrogen (H2) enrichment. This mixture can then be used as fuel for 4-stroke engines and marine boilers, which are not currently able to operate on pure NH3. The project will develop an NH3 cracking unit, which converts NH3 to H2. Onboard storage of H2 can then be avoided, which makes fuel handling and storage safer, cheaper and more efficient. The chemical cracking can utilize waste heat to increases the heating value of the fuel mix significantly. By improving the ignition and combustion properties and utilizing exhaust waste heat, the thermal efficiency in engine combustion is expected to improve as well. The concept will be demonstrated for application in existing dual fuel engine designs. New burner technology will also be developed for boilers. The solutions that the project offers are vital elements within the entire NH3 value chain, as stated in the Innomission 2 Roadmap and the vision is to: 1) couple producers and end users of NH3, 2) support the development of commercially available NH3 ships, and 3) increase the demand for NH3 from bunkering hubs.

As a response to the ongoing environmental and energy crises, Photovoltaics (solar panels) are increasingly being installed on farmland in Denmark and Europe. This development has taken place despite the fact that agricultural land is a scare resource needed to feed the Worlds rapidly increasing food demand. An important next step in this development is AgriPhotoVoltaic systems that benefit from dual use of farm land areas by combining electricity production with agricultural production. This allows for more than agricultural land area carbon neutrality by offsetting the remaining production emissions. However, the present photovoltaics systems are not designed to facilitate cultivation of food crops, but solely for maximizing energy production. AGRIVOLT will in a full-scale experiment investigate the potentials and limitations of using an AgriPV system installed on high-productive farmland. The project consortium consists of the four partners European Energy, Aarhus University, University of Copenhagen and Slagelse Municipality. All partners provide important and complimenting technology and knowledge on photovoltaics, cropping systems and food production, biodiversity, management of field robots and economic and sociological knowledge to secure both the technical and agricultural success of the project and to uncover challenges and solutions for the implementation and path to the market.

E-commerce is booming in the fashion industry with multi-billion dollar market value. 30% of shipped goods are returned with the primary reasons being either wrong size or wrong color, with colors perceived from pictures and videos on the e-commerce web sites. This leads to enormous waste due to unnecessary packaging, shipment and clothes destruction. Today, no software solutions exist for automated true and consistent color alignment across still pictures and videos for professional photographers. The size of this market is currently $1bn and the market is expected to double by 2028. The vision of the AICF project is to reduce the return rate in fashion industry e-commerce by 25% by 2030 due to color issues or 6% in total returns. The mission of AICF is to set new industrial standards by building novel AI-driven automated color-editing for photos and video for professional use. The project combines world class researchers in the fields of AI and photonics with the world leading Danish software company of the field, Capture One, thus providing a unique opportunity to develop new compression formats, UHD monitor support and coloring of moving objects to achieve the most natural colors. When successful, AICF will enable Capture One to defend and expand their current 2-3% market share of the still image color editing market worth 180 mio dkk in 2021 to 10% of the combined still & video market leading to a 1.200 mio dkk market share by 2028.

Food allergy is a major health problem of growing concern, affecting more than 30 million people in US and Europe. Living with food allergy has a tremendous impact on the quality of life, with only trace amounts of allergens being able to trigger severe allergic reactions and potentially death. There are significant unmet medical needs for safe, efficacious, and convenient treatments of food allergies. FDA approved the first drug ever for food allergy immunotherapy (IT) in January 2020, thereby opening tremendous business potential within this emerging market. ALLEVIATE2 aims to develop novel drugs for food allergy sublingual IT (SLIT) with unmatched safety, efficacy and convenience profiles that would significantly improve quality of life of patients. This project will leverage the proprietary therapeutic strategy developed at DTU and successfully applied to develop drug candidates during the IFD funded ALLEVIATE project, as well as the combined research, clinical and business expertise of DTU, SickKids Hospital and ALK, the world leading allergy IT company. ALLEVIATE2 will transfer the therapeutic strategy from peanut allergy IT drug candidates to multiple-nut and complete the preclinical drug discovery phase for peanut and multiple-nut SLIT. Market analysts forecast that ALK can capture a 2-3 BUSD market share in the emerging food allergy IT market, and ALLEVIATE2 represents the first pipeline drugs in the endeavour to realise the growth potential.

AM-Farm will set up the first Danish photopolymerization based Additive Manufacturing (AM) Farm that will cater to agile intermediate-sized production (1000-100,000 components) that can surpass injection molding in agility, and volumetric specific energy consumption (kJ/cm3). While injection molding is highly efficient at scale (>MM components), the energy consumption and tooling costs make it unattractive for intermediate-sized production. AM-Farm is thus the establishment of an autonomous industrial AM facility with an unrivaled productivity, bespoke mass production capability and built on multiple cardinal sustainable innovations. Vat photopolymerization AM (VPP) is the method that is unsurpassed in its capability to produce plastic components at the highest geometrical fidelity. It has revolutionized how bespoke and miniaturized components such as hearing aid shells are manufactured. While in many aspects, an ideal next generation manufacturing process, the wide industrial implementation has been deterred due to considerate amounts of chemical waste generated. AM-Farm congregates a consortium, empowered by new technological advances spun out of academia to set up the world’s first environmentally conscious facility to fully exploit the potential of VPP. The industrial partners aim to exploit the AM-Farm, internally as a next-generation manufacturing method, and as a profitable service available to other Danish manufacturers for intermediate-sized bespoke production.

The future of agricultural production in Denmark and the rest of Europe is dependent on reducing greenhouse gas (GHG) emissions to meet ambitious policy targets to limit climate change, and sustainable solutions to achieve this must be found. Nitrification inhibitors (NIs) are the most promising tool for reducing GHG emissions in agriculture, and are used in soils to increase nitrogen uptake by crops and to reduce emissions of N2O – a potent GHG. The use of NIs is relatively unrestricted, however, their structural similarities to pesticides raise concerns about their safety for the environment and groundwater purity. A more thorough assessment of NI compounds’ environmental impacts is urgently needed. Arla and Danish Crown are two of the largest food companies in Denmark and are committed to reducing agricultural GHG emissions responsibly and sustainably. NIs have the potential to reduce GHG emissions from agriculture by 40% in Denmark, but uncertainty around how they work and what risks they may present to the wider environment means that their widespread application is held back. The amoA project will, in close collaboration with Arla and Danish Crown, produce a novel Impact Evaluation Framework informed by a series of field and lab studies. The framework will allow current and future producers of chemical NIs to secure that a promising technical solution to reduce GHG formation in agriculture does not come at a cost to the soil and water environment.

Aquaculture production is characterized by low carbon emission per kg protein relative to other food producing sectors. Innovation has been driving improvements in the efficiency, competitiveness, and overall sustainability of aquaculture with important progress over the last decade, especially in the field of feed conversion efficiency, and thus further decreasing the carbon footprint. However, efficient and cost-effective control of pathogens remains among the main challenges for the sector, calling for novel green solutions. By developing sustainable strategies to prevent and control bacterial pathogens in trout aquaculture, using bacteriophages, AQUAPHAGE will contribute to increase production efficiency and reducing the environmental burden of aquaculture. The project will produce and test prototype products targeting the bacterial pathogen Flavobacterium psychrophilum (F. p.) in eggs, larvae and juveniles, and bring them to a technological readiness level that allows commercialization post project. The proposed methodology represents a pioneering approach to future sustainable and antibiotic-free aquaculture practices targeting different stages and processes in the production cycle. By targeting this pathogen with novel tools, AQUAPHAGE aims at developing antimicrobial products with a global market potential, reducing the use of antibiotics and supporting a green transition of the aquaculture industry.

Ground- and drinking water are under increasing pressure from a wide range of contaminants and current monitoring strategies are unable to expose the full contaminant picture. Thus, stakeholders in the water supply value chain face the common major problem of not knowing the real water quality of ground- and drinking water. With the AQUAPLEXUS-tool we propose a solution to this problem by developing a novel multi-faceted tool assembling cutting-edge omics-based technologies. The tool comprises the complete chemical fingerprint of water samples and a data storage solution to establish a water data archive for retrospective analysis. Application of the tool will prepare the Danish water suppliers, sub-supplying industry, and authorities for future challenges by: - supporting production of high-quality drinking water - maintaining high consumer trust - inhibit negative health effects - saving time and costs on test and mitigation procedures - complying to new legislation with a minimum of costs - boosting industrial competitive advantages Stakeholders from the entire water supply value chain (water utilities, material suppliers, authorities, commercial analytical laboratories, and researchers) are participating in the AQUAPLEXUS project to ensure compliance with the urgent needs of today’s water supply, readiness for successful implementation of the results in legislation, and exploration of business opportunities incl. export potentials in tests and certified products.

Prostate cancer (PC), the second most common male cancer, affects 1.3 mil men and accounts for +360,000 deaths annually worldwide. At an early stage, local treatments (i.e. surgery, chemical castration and chemotherapy) often cure PC initially. However, an estimated 10-30% progress to metastatic castration-resistant PC (mCRPC) with no curative options, and 70% of patients with mCRPC die within 5 years. This highlights the need for more effective treatments such as immunotherapy with check point inhibitors that has shown remarkable clinical success with other cancer types but minimal efficacy in mCRPC due to the immunologically non-inflammatory nature of PC, characterised by restricted immune cell infiltration. Our approach addresses this unmet need through a bispecific monoclonal antibody, EBM-001, with specificity to Prostate-specific Membrane Antigen (PSMA) and IFNy which: 1) captures and accumulates the patient's own circulating IFNy from the blood: followed by 2) their redistribution to the site of the tumor, igniting an immunological activation by attracting the patient's immune cells to the cancer site. The unique mode of action of EBM-001, will enable a safe long lasting immune infiltration that will improve the efficacy of current immunotherapies for mCRPC. Our consortium (Ebumab, Southern University of Denmark, Bioneer) will use this Grand Solutions project to advance EBM-001 from the current initial proof of concept, to provide in vivo PoC and CMC development.

Access to clean water is a major global issue. Saline and wastewater can be returned to high quality freshwater through reverse osmosis (RO) desalination. The main operational challenge for this process is scaling and biofouling, which decreases RO water recovery and increases energy- and chemical consumption. Conventional RO systems are operated in continuous mode with constant brine salinity. In such systems, fouling organisms adapt and form biofilms on the RO membrane. Operating RO systems in batch mode with fluctuating salinity and intermittent brine discharge can reduce water and energy consumption. However, few such installations exist, and it is not known if batch RO operation can be used to eradicate biofouling. We hypothesize that, with appropriate controls, batch operation of RO will minimize biofouling as alternating salinity hinders the biofilm-forming microorganism´s ability to adapt and proliferate. The aim of BE-SALT is to provide mechanistic insight into biofouling and scaling under fluctuating salt stress implement this knowledge into design and optimization of sensor-based operation of batch RO systems and reduce operational cost (water, energy, chemicals) by >15% compared to continuous RO systems, while enabling high water recovery rates (>75 %) demonstrate the concept in pilot scale and at an end-user Our vision is to lead the way for process design and water/energy efficient operation of RO systems for clean water production.

Denmark has pledged to reach a 70% reduction of greenhouse gas emissions by 2030 and net-zero emissions by 2050. CCS is recognized as an indispensable technology for achieving these ambitious goals. A critical knowledge gap in implementing a CO2 storage project is the phase behavior of CO2+X, where X stands for not just the impurities in the CO2 stream but also the in-situ fluids that interact with CO2. The phase behavior of CO2+X is directly related to many injection risks, such as hydrate formation and salt clogging: it can also affect the development and movement of CO2 plume. Therefore, the phase behavior of CO2+X is crucial to the risk analysis of a CO2 storage project. This project is in collaboration with several industrial partners investigating the feasibility of CO2 storage in different sites in Denmark. The project will provide a systematic study of CO2+X, covering experimental measurement, model development, and simulation analysis. We will measure the critically missing data for CO2+X related to the candidate storage sites, develop highly accurate models, and finally integrate the models into simulation analysis. The emphasis is on integrating our knowledge on CO2+X into the final analysis of injection risks and storage issues. If successful, we will significantly improve the risk analysis of CO2 storage in various types of storage sites and with different impurities, thus accelerating the implementation of CO2 storage.

Speech technology (ST) is a growing industry, with an estimated annual compound growth of 16-19% in the next five years. The majority of ST development is targeted towards high-resource languages, such as English. Danish, as a low-resource language, risks falling behind technologically and missing revenue from this technology. Modern ST is based on ML algorithms, which require large amounts of data. Lack of Danish data is causing Danish ST to fall behind. The CoRal project will remedy this, by creating the first large-scale high-quality dataset consisting of 1,500 hours of transcribed Danish speech, both conversational and read-aloud, comparable in size to English state-of-the-art speech datasets, with eight models, incl. speech recognition and text-to-speech models. The dataset and models will be publicly available and enable use cases which were previously impossible even for some of the largest Danish companies e.g., ATP. Publicly available materials will be developed which will help companies implement the technology and allow SMEs to enter the area with minimal risk, as they can use models and data with almost no prior expertise. In addition, the project will ensure that the dataset represents all variants of spoken Danish, across regiolects, ethnolects, etc. This will allow authorities to provide speech services to all citizens, even marginalized demographics. The scale and diversity of the dataset will push Danish ST up to the highest standard commercially.

Large upfront costs for digital twin (DT) technology and lack of simulation engineering competencies block digital transformation of SMEs in machinery and construction sectors. CP-SENS (cyber-physical sensing for machinery and structures) develops a cost-effective DT framework based on digital sensing units by HBK integrated with an easy-to-use DT software developed by Aarhus University and Aalborg University. CP-SENS accompanies two SMEs, Vestas Aircoil (VA, engine cooler manufacturer) and Vienna Consulting Engineers (VCE, condition monitoring provider), throughout DT transformation and positions HBK, leader in analog sensing technology, into the growing market of digital sensing with a disruptive solution. To eliminate upfront costs, CP-SENS DT is licensed to the non-for-profit INTO-CPS Association and serves the engineering community as a vendor-neutral DT infrastructure. HBK exploits CP-SENS DT as a sale channel by subscribing as a member to the association. To enable DT transformation at national scale, DT know-how is transferred to FORCE Technology and conveyed into a 3-Day DT Crash Course for industry. CP-SENS DT allows VA to increase prototyping capacity by a factor 2 (+12 MEUR/y, +8 jobs in DK) while VCE increases monitoring capacity from 2 to 10 WT park/year (+20 MEUR/y). CP-SENS provides HBK with two strategic entry points to the digital sensing market (+12 MEUR/y, + 10 jobs in DK). Synergy with FORCE Technology enables DT transformation for +200 Danish SMEs.

In order to reach the political climate target of reducing carbon emissions by 70 % in 2030, the Innomission partnership MissionGreenFuels (MGF) aims to accelerate the renewable energy transition. As stressed in the partnership roadmap from 2021, it is critical to ensure support not only from private companies, public authorities and political stakeholders, but also the Danish civil society. Public and private stakeholders experience substantial skepticism and widespread concern from local citizens and interest groups when investors and developers initiate the establishment of vital technologies in the upstream production of green fuels like wind turbines, solar parks and Power-to-X (PtX) plants. To support the mission, this project will develop a national model for citizen engagement in the transition towards green fuels. In collaboration with key partners and with an interdisciplinary social scientific approach, including law, political science and anthropology, the project will design a model that enhances collaboration across scales. The model will thereby guide stakeholders across the green fuels value chain in creating engagement among local citizens. This will lead to three results: 1) Mitigate time consuming and costly conflicts with local citizens and interest groups, 2) provide an innovative environment for collaboration across the value chain, and 3) open a public dialogue for developing an engaged and democratic citizenship within the renewable energy transition.

We urgently need solutions to reduce our resource consumption and waste created. We all see in our everyday cooking how plastic waste piles up with 31 kg of plastic waste produced per EU citizen per year [1]. We need to separate waste to mitigate the problem, and food packaging industries are trying to make new types and more sustainable fossil plastics. However, EAT-pack will develop and provide an edible, environmental and economic sustainable, and safe alternative food packaging solution to re-think, reduce, and revolutionize the future food supply. This breakthrough innovation of edible food film (EFF) either melts or dissolves when boiled, baked or added into the pot, creating no waste. Applications of the EFF concept will be showcased by three scenarios of foods with increasing complexity: 1) rice in portion size, 2) frozen pizza and 3) minced meat that will work as EFF model for a large variety of other types of foods. The company CP Kelco and Mikael Eriksen (private) will together with DTU Food provide technical solutions through development, demonstration, and consumer studies to create this green solution. The Life Cycle Assessment (LCA) of the ready to market EFF will be performed by KU Food. Through conversion of side stream into edible packaging materials, EAT-pack will eliminate the end-of-life treatment corresponding to a reduction of 1.3-2 kg CO2/ ton and create direct revenue of 100 million DKK in 2030.