Prostaglandins are crucial signal molecules in humans, and important drug molecules (also as analogs). PGF2-alpha is biosynthesized in two steps from arachidonic acid (ARA). Currently made by chemical synthesis, long pathways give low yields. We will make a bio-conversion system that makes PGF2-alpha from ARA or glucose, and ID an enzyme that turns PGF2-alpha into an ideal precursor for making the drug Latanoprost. The resulting new process will be greener and more profitable.

Det primære formål med projektet er at udvikle nye komponenter, som kan forlænge og øge effektiviteten af silikonebaserede skibsmalinger. Dette vil kunne bidrage til malingsindustriens rolle i den grønne omstilling inden for den maritime sektor. Mere specifikt vil projektet undersøge sammenhængen mellem design af 'releaseolier' og deres indvirkning på biocidfrie malingssystemer. Det endelige mål er at skabe copolymerer, der effektivt forbedrer og forlænger malingernes levetid.

Danish and European green energy goals and the geopolitical situation makes energy storage diversification ever more crucial. However, the Danish energy storage is dominated by externally acquired chemical/electrochemical batteries. These batteries have limited lifetimes and charging-discharging cycles making recycling problematic and expensive. In this context, we explore an alternative solution to utility scale storage: Flywheel Energy Storage Systems (FESS). With theoretically unlimited number of charging/discharging cycles, reduced costs and manufacturing in Denmark FESS need 25% increase in energy density to compete against the battery solutions. Current market solutions cannot address this issue due to their limits set by design and material concepts. HyFly gathers a sole Danish FESS producer and provider, an advanced composite manufacturer, carbon nanomaterial manufacturer, the material and technology developer and the academia to explore and commercialize graded hybrid composite materials and optimized structural and material design of the FESS rotor. The aim is to increase the speed of the rotor through synergistic developments of production techniques and material and structural designs. This project will map the effects of each component on the final energy density. With the expected energy density increase of min. 25% funding received will be equally spent between the research and development stages, from the material nano- and microscale, up to market solution.

The hospital and caregiving sectors lack a coherent solution to effectively support patients with multimorbidity and their relatives on integrated care pathways. The primary challenges are poor organization and inefficiency in communication and coordination between patients, relatives, and healthcare professionals. Consequently, patients and relatives are burdened with the responsibility of managing tasks, sharing knowledge, repeating information, and ensuring coordination. In response, the I-PARD project has been initiated to improve integrated care pathways for patients with chronic illnesses and their relatives through the implementation of a digital platform solution. The objective is to empower patients and relatives to better handle their own health, leading to improved quality of life for patients with multimorbidity and their relatives. The project develops, tests, and validates a digital solution that, to begin with, will be accessible to patients with Parkinson's disease, acquired brain or spinal cord injuries, their relatives, and healthcare professionals. By enabling coordination, communication, and collaboration across the hospital and caregiving sectors, the project seeks to facilitate improved healthcare experiences for patients and their relatives. Moreover, the project engages stakeholders from various domains, including the formal research community and different sectors, to ensure the most beneficial advancements in integrated care pathways.

Digital interaktion er alle steder, derfor er digital tilgængelighed, brugeroplevelse og effektivitet afgørende for hvor, hvordan og hvem der kan deltage i stadig større dele af samfundslivet. iAnkr er et inputsystem, som ved hjælp af synet, gør brugere i stand til at styre digitale systemer. iAnkr overgår nuværende digital interaktionsteknologi, målt på hastighed, præcision, fysisk slid og fysiske bevægelighedskrav til brugeren. iAnkr er målt til at kunne selektere 300% hurtigere end en muse-cursor. iAnkr kan benyttes med allerede udbredte input-enheder som touch/track-pads samt mere specialiserede enheder, f.eks. alternativer til håndbaseret styring, så som mund-, tunge- eller albue-styringsenheder. iAnkr er kompatibelt med diverse platforme f.eks. PC, mobile og XR. iAnkr kan benyttes direkte, med allerede eksisterende software, som en velkendt, men drastisk forbedret cursor og for applikationer med udvidet iAnkr-understøttelse, kan brugere få gavn af det fulde iAnkr system som yderligere effektiviserer og tilgængeliggør interaktiviteten. iAnkr løfter ikke bare interaktionsoplevelsen og throughput for digitale systemer generelt, men tager XR platformen, fra at være underholdningsfokuseret, til et højproduktivitetsredskab hvor organisation, overblik og interaktion med mange applikationer og datakilder på en gang, bliver lettere og fjerner behovet for investering i f.eks. store PC setup med flere skærme. iAnkr gør det selvsamme virtuelle kontor mobilt uden tab af effektivitet

Healthcare systems worldwide face significant challenges due to shortages of healthcare workers (HCWs), and burnout due to bad work environments. While new hospitals are being built with single-bed patient rooms to ensure privacy and reduce patient infection risks, this architectural design poses additional problems. The physical and mental distance between HCWs and patients increases, and HCWs must oversee more rooms, resulting in fewer patient check-ins. Consequently, patients feel uninformed and isolated, and the risk of adverse events such as falls increases. iAware is an AI-trained workflow technology that prioritizes the well-being of HCWs AND patients. It introduces a virtual "window" that allows patients to stay informed about relevant HCW activities and vice versa. By virtually removing the barriers between patients and HCWs, iAware reduces the need for frequent calls from patients and colleagues, enabling HCWs to work more efficiently. The two-way exchange of information is facilitated by using existing tablets and screens in hospitals. iAware's integrable solution incorporates predictive ward rounds to ensure timely patient visits, patient movement advice, and automated registrations of cleaned and available rooms for optimized room utilization. This approach enables real-time workflow optimization intending to improve the efficiency and the satisfaction of patients and HCWs. See the concept video: rb.gy/pxknf

IMPACT aims to enhance the therapeutic potential of adipose-derived stromal cell (ASC) by refining the understanding and application of an off-the-shelf, allogeneic ASC product for immunomodulatory clinical use. The objectives include generation of high-quality cell products, developing assays to explore and predict the therapeutic potential of ASC, and uncovering the full potential of cell therapy through manufacturing, clinical testing, and innovation. The project involves a multicenter clinical trial, personalized medicine, innovation, and utilizes state-of-the-art production technology. The project addresses knowledge gaps in quantifying differences in ASC functionalities and relationship to clinical effects, an essential prerequisite for progression of ASC-based cell therapy to pivotal trial and commercialization. It focuses on the potential of ASC for treating non-ischemic heart failure and explores advancements in administration. Comprehensive data integration provides understanding of the interplay between cell product and patient, potentially leading to novel identification of mechanisms of action, tailored cell therapies, innovation, and recommendations for future directions. IMPACT will facilitate translation of research into clinical practice. A team of experts with extensive experience in producing therapeutic cell products and conducting clinical trials, will ensure scientific integrity, and the prospect of making an IMPACT by advancing ASC therapy.

Projektet vil kortlægge de bagvedliggende mekanismer for potentielle kobberreducerende teknologier i nutidens antifouling maling til handelsflåden og derved gør det nemmere at minimere brugen af kobber. Der er i disse år regulatorisk fokus på at reducere mængden af kobber i skibenes bundmaling - senest har Korea skærpet kravene med virkning fra 2024/25. Kobberreduktion har både miljømæssige og økonomiske gevinster.

Dette projekt vil systematisk evaluere interaktionen mellem terapeutiske peptider (såsom insulin) og permeationsforstærkere (såsom sodiumcaprate eller C10) under forskellige fysiologiske forhold og dermed frembringe viden om, hvordan man optimerer interaktionen og forbedrer den orale biotilgængelighed for peptidlægemidler. Resultater fra dette mekanistiske studie vil guide og accelerere udviklingen af orale peptid-/proteinlægemidler og dermed adressere det uopfyldte markedsbehov.

INDSIGT er en online platform til medarbejdere på de store kommunale og regionale velfærdsområder. INDSIGT specialiserer sig i mikrolæring, hvis grundlæggende afsæt har et tværfagligt borgersigte. Ved at understøtte medarbejdernes faglige viden, sikres en ensartethed i det daglige borgerrettede arbejde. INDSIGT består af faglig e-læring, i form af film i reelsformat på 3-5 min. med korte tekster og kan i sin generiske form anvendes både som introduktion til nyansatte såvel som erfarne medarbejdere. INDSIGT leverer online ydelser via en web- og appfunktion, hvor medarbejderen enkelt kan bruge materialet enten som opslag eller forberedelse til borgermøder. INDSIGT er daglig on demand kompetenceudviklingsplatform, der sikrer at fagligheden altid er først. Godt fagligt fundament giver en række fordele for den moderne tværfaglige offentlige organisation: transparens i borgerarbejdet, lovmedholdlighed og et mere sikkert økonomisk grundlag, fordi den faglige tone slås rigtigt an fra starten. Der er evidens for, at de mest rentable offentlige organisationer er de, hvor medarbejderne er klædt på til fagligt at håndtere de borgerrettede opgaver, og at der er en forståelse for, hvordan lovgivningen anvendes i praksis. Og vigtigst også på de tilstødende velfærdsområder. INDSIGT vil via AI (faglig myAI) besvare aktuelle spørgsmål fra hverdagspraksis, lægge sig efter brugerens fagprofil og støtte det helhedsorienterede borgerarbejde og sagsopbygningen. INDSIGT er en velfærdspartner i det.

The project aims to address the significant challenges of infertility, particularly focusing on male and female infertility and the related conditions of premature ovarian failure and polycystic ovarian syndrome. The project is a collaboration between Herlev Hospital and XY Therapeutics, a company that target the RANKL signaling pathway, which shows promising potential for improving fertility outcomes. The project also includes Center for Diagnostics who will assist with the development of a companions diagnostic tool. The project builds on an already strong foundation, but will strengthen the scientific and commercial aspects of the technology significantly, by expanding the indication of RANKL inhibition for to men with severely impaired sperm production or no semen production, developing a companion diagnostic tool, and investigating the impact of RANKL modulation on female reproductive function. The project encompasses a mixture of smaller investigative clinical trials and exploratory development activities within infertility. Overall, the project holds potential to make a significant economic and societal impact by providing breakthrough solutions to individuals and couples facing the burden of infertility.