Several chronic diseases such as cancer are complicated by cachexia, a debilitating condition characterised by loss of body weight and muscle mass with negative impact on patients' physical, mental, and social well-being. Cancer cachexia affects 80% of cancer patients and is linked with up to 30% of cancer associated deaths. Current treatment approaches fail to address the multifactorial aspect of the condition, are ineffective, and have adverse side effects. The absence of effective therapies and EMA/FDA approved drugs shows how cancer cachexia is still a major unmet medical need. In DAPHEXIA we will address this large unmet medical need by developing the first solution with potential to address the multifaceted cachexia pathology. Our innovative solution builds on the combination of the natural occurring Ghrelin hormone and Neuropeptide Y (NPY: targeting Y5 receptor) in a single dual acting peptide. We will enable the stimulation of different pathways, in a multimodal approach, with the potential to i) increase appetite, ii) decrease energy expenditure, iii) reduce inflammation, while also iv) reducing muscle wasting. Moreover, by describing the metabolic aspects and the mechanism-of-action of our dual concept we will bring new knowledge to the field cancer cachexia for the benifit of the academic society. Finally, we will by DAPHEXIA develop our selected clinical candidate from the current preclinical stage up to the stage of clinical Phase 1.

In order to reach the political climate target of reducing carbon emissions by 70 % in 2030, the Innomission partnership MissionGreenFuels (MGF) aims to accelerate the renewable energy transition. As stressed in the partnership roadmap from 2021, it is critical to ensure support not only from private companies, public authorities and political stakeholders, but also the Danish civil society. Public and private stakeholders experience substantial skepticism and widespread concern from local citizens and interest groups when investors and developers initiate the establishment of vital technologies in the upstream production of green fuels like wind turbines, solar parks and Power-to-X (PtX) plants. To support the mission, this project will develop a national model for citizen engagement in the transition towards green fuels. In collaboration with key partners and with an interdisciplinary social scientific approach, including law, political science and anthropology, the project will design a model that enhances collaboration across scales. The model will thereby guide stakeholders across the green fuels value chain in creating engagement among local citizens. This will lead to three results: 1) Mitigate time consuming and costly conflicts with local citizens and interest groups, 2) provide an innovative environment for collaboration across the value chain, and 3) open a public dialogue for developing an engaged and democratic citizenship within the renewable energy transition.

Konstant Net og DTU, Distributed Energy systems, vil præcist forudsige tilvæksten i elforbrug med henblik på at forberede en rettidig, omkostningseffektiv udbygning af elnettet til den grønne omstilling. Fremskrivningerne skal ydermere udgøre et kvantitativt grundlag for at agere på et marked for fleksibilitet, således at de eksisterende komponenter kan levetidsforlænges rentabelt. Begge elementer er nødvendige, da mangel på både komponenter og kvalificeret arbejdskraft begrænser udbygningen.