Parkinsons sygdom (PS) er en progressiv, neurologisk sygdom som pt. kun kan behandles symptomatisk. RNA-medicin har vist sig som en lovende farmakologisk klasse til sygdomsmodificerende behandling af neurologiske sygdomme. Dette projekt vil udnytte dette til at udvikle antisense oligonukleotider (ASO) med evnen til at stoppe progressionen af PS. Projektet favner ASO screening, forsøg i PS dyremodeller og non-klinisk udvikling og har potentialet til at markant forbedre livet for PS-patienter.

As fossil fuels are phased out, the ongoing energy transition increases the need for power-to-X (PtX) systems providing anciliary services and converting fluctuating wind/solar power to high-value products such as clean fuels. Electricity constitutes up to 80% of the PtX product cost, therefore, high conversion efficiency is critical. The solid oxide electrolysis (SOE) technology has 40% higher fuel production efficiency than competing alternatives, however limited lifetime is a barrier to SOE commercialization. The ROAD2X consortium will address this barrier by maturing DynElectro’s newly patented (AC:DC) operation that increases SOE lifetime. Additionally, AC:DC operation improves impurity tolerance and enables dynamic operation, important for balancing renewable power production with power consumption. The project prepares AC:DC operated SOE technology for commercialization by 1) demonstrating robust long-term operation (1 year) of SOE cells and a stack 2) investigate the tested cells and stack to identify how AC:DC operation reduces SOE degradation and improves impurity tolerance 3) demonstrating dynamic operation with a 40 kW SOE system 4) designing a power-to-methanol systems with thermally integrated SOE modules. Notably, the generic AC:DC operation method can be used on existing SOE technology from leading manufacturers, which enables rapid implementation and scaling towards large PtX systems for clean fuel production.

RoboE er et nyt end-of-arm-tool til cobots, som gør at små og mellemstore smede- og maskinvirksomheder kan automatisere deres gevindskæringsprocesser, som i dag udføres med manuel arbejdskraft i dårlige arbejdspositioner. RoboE ønsker at forebygge i stedet for at nedslide, og dermed sikre et bæredygtigt arbejdsmarked på længere sigt. Her kommer kollaborative robotter (cobots) ind i billedet. En cobot er en programmerbar robotarm, som er beregnet til at arbejde sammen med mennesker. Den erstatter ikke den ansatte, men løser de arbejdsopgaver, som er fysisk hårde eller gentagende. RoboE kan let tilkobles en cobot og programmeres på få minutter. En typisk kunde for RoboE udfører i dag ca. 20.000 gevindskæringer manuelt om året, svarende til 250 arbejdstimer eller 2 måneders fuldtidsarbejde. Her vil RoboE kunne opnå en besparelse på 90 % i arbejdstid og 80% i produktionstid.

Conventional manual manufacturing methods - hand lay-up and vacuum infusion - are to date predominantly used to produce large-scale Continuous Fiber Composite (CFC) structures for industries such as maritime, automotive, aerospace and wind energy. Conventional manufacturing is labor-intensive and compromises efficiency: manual production steps are posing a safety and quality deficiency risk. RoboPrint revolutionizes conventional manufacturing by establishing a fully automized and digitalized CFC 3D printing process - anticipated to become a game changer in industry demanding high-performance CFC structures by avoiding manual manufacturing limitations. CFC 3D printing enables production of complex geometries and fiber architectures otherwise not feasible with conventional methods. RoboPrint develops and integrates key enabling hardware and software technologies for 3D CFC printing on an industrial scale. On the digitalization side, RoboPrint develops a Digital Twin (DT) of the robotic CFC 3D printer, unifying thermomechanical modelling of the printing process with the virtual robotic printing sequences. Virtual 3D CFC printing enables optimization of the to-be-printed structure prior to physical printing. Interfacing the physical CFC 3D printer with its DT significantly reduces cost, time, safety risk and waste material compared to conventional methods. RoboPrint makes large-scale CFC 3D printing technology ready for demonstration in an industrially relevant environment.