The future of agricultural production in Denmark and the rest of Europe is dependent on reducing greenhouse gas (GHG) emissions to meet ambitious policy targets to limit climate change, and sustainable solutions to achieve this must be found. Nitrification inhibitors (NIs) are the most promising tool for reducing GHG emissions in agriculture, and are used in soils to increase nitrogen uptake by crops and to reduce emissions of N2O – a potent GHG. The use of NIs is relatively unrestricted, however, their structural similarities to pesticides raise concerns about their safety for the environment and groundwater purity. A more thorough assessment of NI compounds’ environmental impacts is urgently needed. Arla and Danish Crown are two of the largest food companies in Denmark and are committed to reducing agricultural GHG emissions responsibly and sustainably. NIs have the potential to reduce GHG emissions from agriculture by 40% in Denmark, but uncertainty around how they work and what risks they may present to the wider environment means that their widespread application is held back. The amoA project will, in close collaboration with Arla and Danish Crown, produce a novel Impact Evaluation Framework informed by a series of field and lab studies. The framework will allow current and future producers of chemical NIs to secure that a promising technical solution to reduce GHG formation in agriculture does not come at a cost to the soil and water environment.