Forskningsprojektet undersøger hvordan førstelinjeledere i produktionen bedst håndterer krydspres sammen med andre. Herunder hvordan de gennem deres handlinger påvirker krydspresset. På baggrund af observation af forskellige strategier ønsker projektet at bidrage til teoriudvikling om ledelsesmæssig håndtering af krydspres og pege på, hvad organisationer kan gøre for at give førstelinjeledere bedre betingelser for at lykkes, der hvor ledelsessystemets ambitioner møder produktionens realiteter.

Shock due to trauma, infection and heart attack affects 10 million patients in USA and EU annually. Prof. Johansson at Rigshospitalet has identified a subgroup (20%) of the shocked patients having TOXic catecholamine release to the blood resulting in acute heart failure with >80% mortality rate. The shocked TOX patients can be identified by the biomarker succinic acid > 10nM in the blood enabling targeted treatment with beta1-selective blocker, which according to published observational data, will reduce mortality by 50%. A PCT application has been filed by Rigshospitalet concerning this[WO2022/233994 A1]. The TOX project will validate the 10nM cut-off level of succinic acid to identify TOX in 500 patients with septic shock by mass spectrometry using an existing biobank at Rigshospitalet. A point-of-care biosensor will be developed at DTU Bioengineering that measure succinic acid in plasma in the required nM range to be used in a proof-of-concept trial in 200 TOX patients with septic shock evaluating the effect of beta1-selective blockers vs. placebo on 30-day mortality conducted at Copenhagen University Hospitals. The result of the trial including a Health Technology Assessment conducted by VIVE will be used to implement the TOX test globally through license agreements, partnering or take-over with global diagnostic companies, and MoxieLab ApS, a spin-out from Rigshospitalet, now owning the IP. Roche Diagnostics has already shown interest in the technology.

Projekt søger at udvikle modeller der kan bestemme niveauet af kommunikationsbesvær for folk med høretab. Data fra laboratorier og fra den virkelige verden benyttes, så modellerne kan evalueres under forskellige forhold. I den virkelige verden opsamles data vha. høreapparater, sensorer, og smartphones, og in-situ spørgeskemaer benyttes til at forstå oplevet kommunikationsbesvær. Forskellige høreapparatindstillinger vil blive anvendt for at fastslå modellernes sensitivitet.

I EU's nuværende brintøkonomi er det kun 4% af projekterne, der når frem til den endelige investeringsbeslutning, sandsynligvis på grundet manglen af et brintmarked og optimale investeringsstrategier. Dette projekt har til formål at tackle disse udfordringer ved at designe et brintmarked, der er i overensstemmelse med brints fysiske egenskaber, at udvikle et værktøj til at støtte interessenter i at deltage i et sådan marked og at kvantificere den socioøkonomiske indvirkning af ovenstående mål.

I pumpeindustrien er der en stigende efterspørgsel efter integrerede sensorløsninger, som kan levere indsigt i pumpens operation og tilstand. Dette skal muliggøre optimering af pumpens og pumpesystemets drift, samt forhindre uventet nedbrud. Dette opnås i dag typisk ved omkostningstunge sensorløsninger, som eftermonteres uden på pumpen. Projektet fokuserer på, hvordan dette kan opnås med integreret sensorik og motorstrømsanalyse til en kommercielt attraktiv pris.

Der er en global læsefærdighedskrise – læsefærdigheder blandt 15-årige er faldet dramatisk i løbet af de sidste 10 år (PISA). En ud af 5 lider af ordblindhed, verdens største læse- og skriveforhindring. Forældre i EU og USA bruger titusindvis af milliarder af euro med undervisere for at hjælpe deres børn med ordblindhed med at få succes. Through Line, en digital ledsager og vejleder, hjælper mennesker med ordblindhed at få læse-, skrive- og tale flydende hurtigere og mere omkostningseffektivt.

Creatives Combined: Distributed marketing content creation for enterprises. CC fulfills the creative potential of brands. We give tools to each stakeholder in the sales process that enable them to deliver the right message, to the right person, at the right time. CC reduces up to 90% of marketing content spending while producing flexible and relevant media. Marketing depends upon delivering the right message, to the right person, at the right time meaning trying to match as many customer segments with specific messages whilst still maintaining coherence.Yet, the resources required for tailoring content,restrict the ability of organizations to target audiences on a granulated level.This creates a tradeoff where brands are forced to balance budgets between creativity and production.We know companies “play safe” and are used to spend 80% of marketing budgets(corresponding to 15.1% of revenue in B2C) in supporting sales while sacrificing creative potential.This means always having a wasteful campaign where brands can never fulfill their sales potential. This needs not to be.Democratizing content creation is necessary to fulfill the potential within brand messaging. We offer an AI based tool that brings creative flexibility to content production saving up to 90% of creation cost without creative tradeoffs and targeting mistakes.

In the modern digital age, secure communication is paramount for global commerce, governance, and security. While classical cryptographic techniques have been effective, they remain vulnerable to computational advances, especially the forthcoming quantum computing era. Quantum Key Distribution (QKD) with AES encryption emerges as a formidable, quantum-resistant alternative, but current QKD systems face challenges in scalability, performance, and practicality. CyberQ seeks to develop next-generation QKD systems that address these gaps, providing scalable, affordable, and robust cryptographic solutions. In doing so, CyberQ capitalizes on a business opportunity in the quantum cryptography market, projected to exceed $1 billion by 2030, while also improving security across vital sectors like banking, healthcare, and governmental agencies. This initiative aligns with national and EU strategic priorities, such as the European Quantum Flagship program, the EuroQCI initiative and the Danish strategy for quantum technology where cybersecurity is emphasized. Scientifically, CyberQ's ambition is to advance the Continuous Variable (CV) QKD system to ensure enhanced security and adaptability in intricate quantum networks. The endeavor follows three development paths: intensifying CVQKD system security, refining multi-party protocols for broader network application, and improving system resilience and miniaturization for cost-effectiveness and broad deployment.

Husheye er en innovativ startup, der har udviklet et støjreducerende cover til varmepumper. Med stigende fokus på bæredygtige energiløsninger er varmepumper blevet en populær valgmulighed for mange husejere. Dette har dog medført en udfordring i form af støjgener, der kan påvirke både brugere og deres naboer negativt. Husheye's løsning adresserer dette problem direkte ved at tilbyde en effektiv støjdæmpning. Markedspotentialet er enormt, ikke kun fordi antallet af varmepumper forventes at stige betydeligt i de kommende år. Vores idé har potentialet til at gøre en mærkbar forskel for samfundet ved at facilitere overgangen til grønnere energikilder. Ved at reducere støj fra varmepumper gør vi det mere attraktivt for husejere at vælge denne bæredygtige løsning, hvilket kan bidrage til en reduktion i CO2-udledningen. Investering fra Innovationsfonden vil være afgørende for at bringe vores projekt til det næste niveau. Midlerne vil blive anvendt til videreudvikling af vores teknologi, herunder optimering af vores støjreducerende materialer og design, samt til at skabe opmærksomhed omkring vores produkt. Dette vil accelerere vores vej til markedet. På langt sigt har Husheye potentiale for vækst ved at innovere og udvide vores sortiment med løsninger for diverse varmepumper. Vi øjner også international vækst, idet efterspørgslen er global. Med en solid forretningsstrategi og Innovationsfondens støtte, sigter vi mod at blive førende inden for støjreduktion af varmepumper.

Several chronic diseases such as cancer are complicated by cachexia, a debilitating condition characterised by loss of body weight and muscle mass with negative impact on patients' physical, mental, and social well-being. Cancer cachexia affects 80% of cancer patients and is linked with up to 30% of cancer associated deaths. Current treatment approaches fail to address the multifactorial aspect of the condition, are ineffective, and have adverse side effects. The absence of effective therapies and EMA/FDA approved drugs shows how cancer cachexia is still a major unmet medical need. In DAPHEXIA we will address this large unmet medical need by developing the first solution with potential to address the multifaceted cachexia pathology. Our innovative solution builds on the combination of the natural occurring Ghrelin hormone and Neuropeptide Y (NPY: targeting Y5 receptor) in a single dual acting peptide. We will enable the stimulation of different pathways, in a multimodal approach, with the potential to i) increase appetite, ii) decrease energy expenditure, iii) reduce inflammation, while also iv) reducing muscle wasting. Moreover, by describing the metabolic aspects and the mechanism-of-action of our dual concept we will bring new knowledge to the field cancer cachexia for the benifit of the academic society. Finally, we will by DAPHEXIA develop our selected clinical candidate from the current preclinical stage up to the stage of clinical Phase 1.

Projektet fokuserer på udvikling af datadrevne komponenter til brug i simuleringer. Målet er at reducere beregningsressourcerne, der kræves for at køre modellerne. Forskningshypotesen er, at det er muligt at optimere fysik- og ekspertvidenskabsbaserede simuleringer ved hjælp af automatisk indsamlet data og AI. Ph.d.-projektets fokus er at udvikle metoder til at opdage flaskehalse og udvikle datadrevne simuleringer som erstatningsmodeller, der skal bruges sammen med traditionelle simuleringer.